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首页> 外文OA文献 >Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration.
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Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration.

机译：口服后，匹莫林在血浆，唾液和尿液中的药代动力学。

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1 Pemoline concentrations were measured in plasma and saliva following a single oral dose (37.5 or 50.0 mg) to healthy volunteers. In addition urinary excretion rates and cumulative urinary excretion of the parent compound and its oxazolidinedione metabolite were determined. 2 The plasma curves exhibited a mean elimination half-live of 11.0 +/- 1.2 h (n=4). Peak levels were reached at 2.7 +/- 0.6 h (n=4). The saliva concentrations were about 50% lower than the corresponding plasma concentrations during the elimination phase. During the absorption phase irregularities in the saliva to plasma concentration ratios were observed. 3 In urine 47.0 +/- 8.4% of the dose (n=6) administered was excreted as unchanged drug and only 3.7 +/- 0.8% (n=3) as the oxazolidinedione metabolite. Urinary half-lives were slightly shorter than the corresponding plasma half-lives.
机译：1对健康志愿者单次口服剂量（37.5或50.0 mg）后，测定血浆和唾液中的Pemoline浓度。另外，测定母体化合物及其恶唑烷二酮代谢物的尿排泄率和累积尿排泄。 2血浆曲线显示平均消除半衰期为11.0 +/- 1.2小时（n = 4）。在2.7 +/- 0.6小时（n = 4）达到峰值水平。在消除阶段，唾液浓度比相应的血浆浓度低约50％。在吸收阶段，观察到唾液与血浆浓度之比的不规则性。 3尿液中47.0 +/- 8.4％的剂量（n = 6）作为未改变的药物排泄，只有3.7 +/- 0.8％（n = 3）的恶唑烷二酮代谢物排泄。尿半衰期略短于相应的血浆半衰期。

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